Table 12.
NBPT residue summary in edible tissues
| Average NBPT concentration in tissues (ppm)a | |||||
|---|---|---|---|---|---|
| Phase of study | Day within dosing phase | Tissue type | Treatmentb | ||
| 1× | 3× | 10× | |||
| Dosing | 28 | Liver | NA | NA | BQL |
| Kidney | NA | NA | BQL | ||
| Muscle | NA | NA | BQL | ||
| Mesenterial fat | NA | NA | BQL | ||
| Perirenal fat | NA | NA | BQL | ||
| Subcutaneous fat | BQL | BQL | 0.123 | ||
| Depuration | 3 | Liver | — | — | BQL |
| Kidney | — | — | BQL | ||
| Muscle | — | — | BQL | ||
| Mesenterial fat | — | — | BQL | ||
| Perirenal fat | — | — | BQL | ||
| Subcutaneous fat | — | — | BQL | ||
| 7 | Liver | — | — | BQL | |
| Kidney | — | — | BQL | ||
| Muscle | — | — | BQL | ||
| Mesenterial fat | — | — | BQL | ||
| Perirenal fat | — | — | BQL | ||
| Subcutaneous fat | — | — | BQL | ||
| 14 | Liver | — | — | BQL | |
| Kidney | — | — | BQL | ||
| Muscle | — | — | BQL | ||
| Mesenterial fat | — | — | BQL | ||
| Perirenal fat | — | — | BQL | ||
| Subcutaneous fat | — | — | BQL | ||
NA = not analyzed.
aMean of data from three cows from the 1×, 3×, and 10× groups during the dosing phase (days 28). In the depuration phase, each day of study represent a single cow from the 10× group.
bTreatments correspond to target NBPT doses as follows: 1× = 1 mg NBPT per kg BW; 3× = 3 mg NBPT per kg BW; 10× = 10 mg NBPT per kg BW. Target dose values calculated based on the average BW of the dose group from the previously completed week.
cBQL = Below lower limit of quantitation (0.04 ppm). BQL values from individual samples were set to 0 for calculation of mean values