Table 3.

Dose calculations

Treatment	Target NBPT dose levels (mg/ kg BW)a	Dose week	Group average BW (kg)b	Total dose per day
				(mg a.i)c	(mg)
1×	1	1	532.5	532.5	545.6
		2	538.5	538.5	551.7
		3	543.2	543.2	556.6
		4	553.0	553.0	566.6
3×	3	1	524.5	1,573.5	1,612.2
		2	529.0	1,587.0	1,626.0
		3	526.3	1,578.9	1,617.7
		4	535.8	1,607.4	1,646.9
10×	10	1	552.7	5,527.0	5,662.9
		2	553.6	5,536.0	5,672.1
		3	551.4	5,514.0	5,649.6
		4	548.3	5,483.0	5,617.8

a.i., actual intake; TDL, target dose level.

Total dose per day (mg a.i.) = [BW (kg)] × [TDL (mg NBPT/kg BW)]. Total dose per day (mg) = [BW (kg)] × [[TDL (mg NBPT/kg BW)]/purity (97.6%)].

^aThe amount of NBPT for each animal’s daily dose was calculated based on the average BW of the dose group from the previously completed week.

^bValues taken from Table 8.

^cBased on 97.6% purity in the test substance.