Table I.

Reported response to treatments attempted for GGD

Study	Patient age/sex	Clinical morphology	Suprabasal acantholysis	Lentiginous changes	Dyskeratosis	Genetic testing	Treatment (response)
Braun-Falco et al (2001)8	53/M	Brown pigmentation in skin folds with chronic pruritic papular eruption of neck, axilla, lateral trunk, dorsal hands, groin	+	+	-	NT	Tretinoin 0.03% and urea 12% creams (pruritus worsened, irritation) Ultraviolet B phototherapy (slight antipruritic and stabilizing effect) Systemic and topical corticosteroids (short-term partial improvement)
Cooper et al (2004)9∗	42/F	Pruritic, erythematous scaly papules and vesicles and lentigines of forehead, upper back, chest, and lower extremities	+	+	+	(-) ATP2A2	Emollients (pruritus controlled)
Cooper et al (2004)9∗	39/F	Erythematous papules and tan lentigines of extremities, trunk, and neck	+	-	-	(-) ATP2A2	Topical retinoids (no improvement)
El Shabrawi-Caelen et al (2007)7	65/F	Recurrent pruritic erythematous and brown macules and papules, some with scale over trunk, flexural and extensor lower extremities	+	+	+	NT	Topical corticosteroids (no improvement) Topical retinoids (no improvement)
El Shabrawi-Caelen et al (2007)7	67/F	Pruritic erythematous and lentigo-like macules of inframammary skin, lower extremities	+	+	-	NT	Topical and oral corticosteroids (incomplete resolution) Topical and oral retinoids (incomplete resolution) Ultraviolet B phototherapy (incomplete resolution)
Gilchrist et al (2008)6	41/M	Confluent pink and tan macules and papules, reticular hyperpigmentation of neck, chest, back, proximal extremities	+	+	-	NT	Prednisone and cyclosporine (pruritus improved, eruption persisted)
Gomes et al (2011)10	67/F	Recurrent pruritic erythematous hyperkeratotic papules and brown macules of extensor and flexural surfaces, dorsal hands, neck, trunk	+	+	+	NT	Topical corticosteroids (no improvement) Acitretin, 25 mg/d (short-term partial improvement)
Müller et al (2008)11	52/M	Brown reticulate macules of flexures, neck, groin, and trunk	+	+	-	NT	Topical corticosteroids (short-term improvement)
Müller et al (2008)11	25/M	Pruritic papules, brown macules of trunk, neck, flexures, axillae, inguinal folds, hands, acneiform papules of back, neck, and face	+	+	-	NT	Topical corticosteroids (no improvement)
Voth et al (2011)13	68/M	Chronic pruritic erythematous hyperkeratotic papules of axillae, neck, trunk, and groin	+	+	-	c.418dupA KRT5 gene	Topical corticosteroids (no improvement) Topical antibiotics (no improvement) Oral antihistamines (no improvement) Erbium:YAG laser (dyspigmentation, resolution of symptoms)
Desai et al (2016)12	55/F	Hyperpigmented reticulated macules of neck, chest, abdomen, extensor and flexor surfaces of upper and lower extremities	+	+	-	NT	Topical retinoids (no response reported)
Dupuy et al (2018)14	58/F	Hyperkeratotic, red-brown flat-topped papules with background of lentigo-like macules on trunk, upper and lower extremities	+	+	+	NT	Acitretin (improved rash, discontinued due to hair loss) Triamcinolone 0.1% cream (pruritus and erythema improved) Isotretinoin, 30-40 mg/d (pruritus and erythema improved, discontinued due to “blistering” skin reaction)
Lőrincz et al (2018)15	74/M	Hypopigmented papules, hyperpigmented macules of neck, trunk, and flexor extremities	+	+	-	c.418dupA KRT5 gene	Acitretin, 25 mg every other day to daily (inflammatory eruption and pigmentation improved)
Current case	84/F	Pruritic crusted and scaling pink papules and tan macules of trunk, neck, flexor and extensor extremities	+	+	+	c.652>T POGLUT1 gene	Prednisone, 40 mg (no improvement) Topical corticosteroids (no improvement) Doxepin, 20 mg nightly (no improvement) Acitretin, 10-25 mg/d (pruritus and papular eruption resolved)

NT, Not tested.

^∗Authors hypothesized diagnosis of widespread Grover disease with lentiginous changes.