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. 2020 Apr 25;17:894–903. doi: 10.1016/j.omtm.2020.04.014

Figure 5.

Figure 5

Intravitreal Delivery of scAAV2-C3 Eased Neuronal Cell Loss in the GCL after I/R Injury

(A) Representative images of NeuN immunofluorescence in the scAAV2-C3, scAAV2-C3 + I/R, scAAV2-EGFP, scAAV2-EGFP + I/R, blank control, and blank control + I/R groups. The NeuN-positive cells localized predominantly in the GCL and showed weak fluorescence in the INL. Blue, DAPI; red, NeuN-positive cell. (B) Quantitative analysis of NeuN-positive cells per 300 μm of retina length in each group. ∗p < 0.05 by an LSD post hoc test (n = 3); †p < 0.05 versus the scAAV2-EGFP + I/R group by an LSD post hoc test (n = 3), and the blank control + I/R group by an LSD post hoc test (n = 3). No statistically significant difference (p > 0.05) was detected by an LSD post hoc test between the scAAV2-EGFP + I/R and the blank control + I/R groups (n = 3), or among the scAAV2-C3, scAAV2-EGFP, and blank control groups (n = 3). Error bars show SEM.