Figure 2. The proteostasis network.

Cells employ several mechanisms to maintain proteins integrity and minimize non-native or harmful protein conformations. Mechanisms are in place for proteome quality control. Redox signalling participates in proteostasis by modulating the folding, misfolding, (dis)aggregation and the extent of toxicity of protein aggregates. References to examples of the various steps are indicated in numbers. Note that in some cases it is not clear from the literature what exact step in aggregation is affected, or whether multiple steps are affected, and in this case, the reference is denoted at the first transition from native to partially unfolded.