Skip to main content
. 2020 Apr 20;48(2):667–675. doi: 10.1042/BST20191110

Figure 1. Model for IL-6 induced reactivation in dendritic cells.

Figure 1.

The MIEP of HCMV is associated with heterochromatin in latently infected CD34+ cells (A). Concomitant differentiation to a dendritic cell phenotype and activation of inflammatory IL-6 signaling initiates ERK–MAPK and SFK signaling. The activation of ERK promotes activation of mitogen and stress-activated kinases 1 and 2 (MSKs) which recognize the CREB transcription factor bound to the MIEP (B). Recruitment of MSK via CREB to the MIEP promotes dual phosphorylation of CREB and also histone H3 at serine 10 (C). Phosphorylation of serine 10 de-stabilizes the binding of HP-1 to methylated lysine 9 residues promoting its dissociation from the MIEP (D). This activation of SFK promotes the recruitment of MOZ histone acetyltransferase activity to the MIEP (D) which drives histone acetylation facilitating the robust induction of MIE gene expression (E) — the first event in full viral reactivation.