Table 2. Recently reported structures of small molecule inhibitors of E3 ligases.
Target | Compound ID | Structure | Reference |
---|---|---|---|
TRAF6 | 1, C25-140 | Brenke et al. [62] | |
RNF4 | 2, TRH 1-23 | Ward et al. [63] | |
3, CCW16 | |||
VHL |
4a: X = F, Z = H 4b: X = H, Z = F |
Testa et al. [64] | |
WWP2 | 5 | Watt et al. [65] | |
6 | |||
7 | |||
8 | |||
9 | |||
SMURF1 | 10, HS-152 | Tian et al. [66] | |
HOIP | 11, Bendamustine | De Cesare et al. [67] | |
12 | Johansson et al. [68] | ||
13 | |||
14 |