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. 2020 May 5;10:7516. doi: 10.1038/s41598-020-64485-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Northern blot quantification of tRFs in epilepsy patient plasma. (A) RNA extracted from plasma samples collected pre and post seizure from 4 epilepsy patients was analysed by northern blot. 20 ul total RNA was electrophoresed on a 15% gel and transferred to a nitrocellulose membrane and probed with dual digoxigenin-labelled probes for tRNA fragments and the C.elegans spike-in added during RNA purification. (B) Densitometric quantification of northern blot signals indicates all three tRNA fragments are higher in pre-seizure compared to post seizure samples.