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. 2020 May 5;10:7563. doi: 10.1038/s41598-020-64298-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of accumulation of αSMA-positive cells through Twist1-PDGFB signaling. Schematic illustration demonstrating that endothelial Twist1 stimulates PDGFB expression and mediates hypoxia-induced αSMA-positive cell accumulation in the gel implanted on the mouse lungs. Endothelial Twist1 also mediates accumulation of αSMA-positive cells in the gel supplemented with human IPAH patient-derived ECs and implanted on the mouse lungs. PDGFR: PDGF receptor.