Skip to main content
. 2020 May 5;11:2206. doi: 10.1038/s41467-020-16067-1

Fig. 2. Distribution of germline pathogenic/likely pathogenic (P/LP) mutations in children, adolescents, and young adults (C-AYA) with solid tumors.

Fig. 2

a Top mutated genes with germline P/LP variants in KCPG (left panel) and candidate genes (right panel) and their type of alterations. b Oncoplots of top mutated genes with P/LP variants in known cancer-predisposing genes (KCPG) (top panel) and candidate genes (lower panel) based on the age group. Each column represents one patient and its affected genes. c Most frequently mutated genes with P/LP variants in KCPG (left panel) and candidate genes (right panel) based on their affected tumor types. ACT adrenocortical carcinoma, BCC basal cell carcinoma, CA carcinoma, CNS central nervous system, EWS Ewing sarcoma, GCT germ cell tumor, GICT giant cell tumor, HGG high-grade glioma, LGG low-grade glioma, LMPRT low malignancy potential renal tumor, NBL, neuroblastoma, NM non-malignant tumor, OS osteosarcoma, OST other solid tumors, PGL paraganglioma, RB retinoblastoma, RCC renal cell carcinoma, RHB rhabdomyosarcoma, STS soft tissue sarcoma, WLM Wilms tumor, Del deletion, Ins insertion.