Table 2.
Demographics and clinical characteristics of patients.
| Source | CCF/PCGP/SJLIFE | ||||
|---|---|---|---|---|---|
| Age group | Children | Adolescent | Young adult | Unknown | Total |
| Female/Male | 600/582 | 67/97 | 5/15 | 14/13a | 686/707 |
| Mean age of onset | 6.1 ± 4.5 | 16.9 ± 1.3 | 22 ± 2.4 | NA | 7.6 ± 5.8 |
| All solid tumors (1507) | 1182 | 164 | 20 | 141 | 1507 |
| Central nervous system (323) | 266 | 23 | 2 | 32 | 323 |
| Wilms tumor (207) | 189 | 2 | 1 | 15 | 207 |
| Neuroblastoma (190) | 158 | 2 | 1 | 29 | 190 |
| Rhabdomyosarcoma (134) | 114 | 14 | 1 | 5 | 134 |
| Osteosarcoma (129) | 78 | 42 | 5 | 4 | 129 |
| Retinoblastoma (98) | 84 | 14 | 98 | ||
| Ewing’s sarcoma (95) | 58 | 27 | 5 | 5 | 95 |
| Soft tissue sarcoma (93) | 69 | 17 | 3 | 4 | 93 |
| High-grade glioma (80) | 63 | 8 | 9 | 80 | |
| Germ cell tumor (74) | 57 | 11 | 1 | 5 | 74 |
| Low-grade glioma (24) | 8 | 1 | 15 | 24 | |
| Adrenocortical carcinoma (22) | 20 | 1 | 1 | 22 | |
| Carcinoma (14) | 7 | 7 | 14 | ||
| Giant cell tumor (3) | 0 | 3 | 3 | ||
| Renal cell carcinoma (3) | 2 | 1 | 3 | ||
| Low malignant potential renal tumors (2) | 2 | 2 | |||
| Basal cell carcinoma (1) | 1 | 1 | |||
| Paraganglioma (1) | 1 | 1 | |||
| Other solid tumor (10) | 3 | 4 | 3 | 10 | |
| Non-malignant tumor (4) | 3 | 1 | 4 | ||
CCF Cleveland Clinic Foundation, PCGP Pediatric Cancer Genome Project, SJLIFE, St. Jude Life Cohort. aGender data were not available for all the patients in this group.