Table 1.

Validation of the LV mass polygenic predictor (PRS).

Data source	Independent variable	Additional covariatea	OR (95% CI)b	P-value
Derivation setc	LV Mass measured	None	2.1 (2.0–2.3)	<2 × 10−16
	LV Mass PRS	None	2.0 (1.9–2.1)	<2 × 10−16
	LV Mass PRS	LV Mass measured	1.1 (0.99–1.31)	0.06
	LV Mass PRS	Height	2.0 (1.9–2.2)	<2 × 10−16
	LV Mass PRS	BMI	1.9 (1.8–2.1)	<2 × 10−16
	LV Mass permuted PRS	None	0.99 (0.94–1.04)	0.66
Validation set 1: BioVUd	LV Mass PRS	None	1.08 (1.02–1.13)	0.002
Validation set 2: eMERGEe	LV Mass PRS	None	1.10 (1.06–1.14)	4.1 × 10−7

^aAdditional covariate added to the logistic regression model.

^bAnalyses are based on a logistic regression model using the PheWAS phenotype cardiomegaly as the dependent variable and specified independent variable. All independent variables were set to have a standard deviation of 1. All models were additionally adjusted for age, sex and 5 principal components.

^cThe data set used to develop the PRS. There were 2929 cases and 3416 controls for cardiomegaly.

^dCases (n = 2,624) and controls (n = 16,682) for the cardiomegaly phenotype that were not part of the derivation set.

^eCases (n = 5,982) and controls (n = 21,198) for the cardiomegaly phenotype that were not part of the derivation set.