Table 2.

Associations between genetic predictors for selected risk factors and LV mass, by sex.

Risk factor	Males	P-value	Females	P-value
	Change in LV Massa		Change in LV Massa
Inverse-variance weighted average meta-analysis
Body mass index	0.079 (0.015)	1.2 × 10−7	0.147 (0.016)	1.7 × 10−20
Systolic blood pressure	0.004 (0.002)	0.03	0.001 (0.001)	0.29
Coronary artery disease	0.027 (0.013)	0.03	−0.002 (0.014)	0.87
Type 2 diabetes (T2D)	−0.001 (0.008)	0.92b	0.018 (0.008)	0.02
T2D, excluding BMI SNPsd	0.017 (0.015)	0.25	−0.008 (0.015)	0.62
MR-Egger method
Body mass index	0.146 (0.047)	0.002	0.168 (0.050)	0.001
Systolic blood pressure	0.002 (0.007)	0.7	0.000 (0.007)	0.95
Coronary artery disease	0.044 (0.030)	0.15	−0.040 (0.033)	0.23
Type 2 diabetes (T2D)	−0.042 (0.018)	0.02c	0.004 (0.019)	0.82
T2D, excluding BMI SNPsd	−0.026 (0.046)	0.58	0.049 (0.049)	0.31
Weighted median method
Body mass index	0.114 (0.025)	4.0 × 10−6	0.145 (0.029)	6.8 × 10−7
Systolic blood pressure	0.003 (0.003)	0.24	−0.002 (0.003)	0.51
Coronary artery disease	0.037 (0.020)	0.06	−0.020 (0.022)	0.37
Type 2 diabetes (T2D)	−0.017 (0.014)	0.23	0.008 (0.015)	0.6
T2D, excluding BMI SNPsd	0.006 (0.023)	0.81	−0.003 (0.025)	0.9

^aEstimates (standard error) represent the changes in the log(LV mass) per unit change of the risk factor.

^bHeterogeneity p < 0.05.

^cMR-Egger intercept p < 0.05.

^dExcludes SNPs associated with BMI at p < 0.05.