Table 5.
Full diagnostic (logistic) model for pancreatic cancer, including the intercept.
| Intercept and Predictors | Coefficient | SE | OR | 95% CI | P value | VIF | Sensitivity | Specificity | Opt Cutoff |
|---|---|---|---|---|---|---|---|---|---|
| Cluster 1 | |||||||||
| Intercept | 20.04426 | 3.258 | — | — | |||||
| mir125a3p | −0.103 | 0.029 | 0.90 | 0.85–0.95 | <0.0001 | 1.88 | |||
| mir92a25p | −0.140 | 0.028 | 0.86 | 0.82–0.91 | <0.0001 | 2.14 | |||
| mir4530 | −0.111 | 0.028 | 0.89 | 0.84–0.94 | <0.0001 | 2.34 | |||
| Mean VIF | 2.12 | ||||||||
| AIC/ BIC | 63.79/ 79.28 | ||||||||
| McFadden’s Pseudo R2 | 0.8853 | ||||||||
| Hosmer-Lemeshow GOF | X2 = 1.30, P value= 0.9956 | ||||||||
| ROC area (95% CI) | 0.9964 (0.99287–0.99990) | 0.98 | 0.95 | 0.576 | |||||
| Cluster 2 | |||||||||
| Intercept | −22.92 | 5.751 | |||||||
| mir5100 | 0.080 | 0.045 | 1.08 | 0.99–1.18 | 0.079 | 5.85 | |||
| mir8073 | 0.152 | 0.052 | 1.16 | 1.05–1.29 | 0.004 | 5.47 | |||
| mir642b3p | 0.107 | 0.056 | 1.11 | 0.99–1.24 | 0.056 | 4.64 | |||
| mir663a | 0.126 | 0.053 | 1.13 | 1.02–1.26 | 0.019 | 4.15 | |||
| Mean VIF | 5.03 | ||||||||
| AIC/ BIC | 31.13/ 50.50 | ||||||||
| McFadden’s Pseudo R2 | 0.9565 | ||||||||
| Hosmer- Lemeshow GOF | X2 = 11.81, P value= 0.1598 | ||||||||
| ROC area (95% CI) | 0.9995 (0.99844–1.00000) | 0.99 | 0.98 | 0.553 | |||||
| Cluster 3 | |||||||||
| Intercept | −3.793 | 3.393 | |||||||
| mir8073 | 0.22 | 0.051 | 1.25 | 1.13–1.38 | <0.0001 | 1.26 | |||
| mir92a25p | 0.17 | 0.037 | 1.19 | 1.10–1.28 | <0.0001 | 2.02 | |||
| mir5100 | −0.23 | 0.059 | 0.79 | 0.70–0.89 | <0.0001 | 2.00 | |||
| Mean VIF | 1.76 | ||||||||
| AIC/ BIC | 55.25611/ 70.74458 | ||||||||
| McFadden’s Pseudo R2 | 0.9028 | ||||||||
| Hosmer- Lemeshow GOF | X2 = 2.22, P value= 0.9735 | ||||||||
| ROC area (95% CI) | 0.9970 (0.99334–1.00000) | 0.98 | 0.97 | 0.688 | |||||
| Cluster 4 | |||||||||
| Intercept | −7.466 | 2.528 | |||||||
| mir4668 | 0.142 | 0.045 | 1.15 | 1.05–1.26 | 0.002 | 6.63 | |||
| mir663a | −0.11 | 0.027 | 0.89 | 0.84–0.94 | <0.0001 | 3.51 | |||
| mir125a3p | 0.109 | 0.039 | 1.11 | 1.03–1.20 | 0.005 | 4.65 | |||
| Mean VIF | 4.93 | ||||||||
| AIC/ BIC | 49.65036/ 65.13883 | ||||||||
| McFadden’s Pseudo R2 | 0.9144 | ||||||||
| Hosmer- Lemeshow GOF | X2 = 2.22, P value= 0.9735 | ||||||||
| ROC area (95% CI) | 0.90 (0.89–0.95) | 0.96 | 0.90 | 0.589 | |||||
| Cluster 5 | |||||||||
| Intercept | 3.966 | 5.754 | |||||||
| mir125a3p | −0.382 | 0.166 | 0.68 | 0.49–0.94 | 0.021 | 1.91 | |||
| mir5100 | 0.242 | 0.089 | 1.27 | 1.06–1.51 | 0.007 | 2.13 | |||
| mir642b3p | 0.216 | 0.083 | 1.24 | 1.05–1.46 | 0.010 | 2.54 | |||
| Mean VIF | 2.19 | ||||||||
| AIC/ BIC | 23.29147/ 38.77994 | ||||||||
| McFadden’s Pseudo R2 | 0.9686 | ||||||||
| Hosmer- Lemeshow GOF | X2 = 0.03, P value= 1.0000 | ||||||||
| ROC area (95% CI) | 0.95 (0.92–0.99) | 0.97 | 0.93 | 0.401 | |||||
SE: Standard error. OR: Odds Ratio. X2: Chi square statistic. GOF: Goodness of fit. ROC = Receiver-operating characteristic. VIF: variance inflation factor