Table 5.
Time-Dependent Cox Regression Analysis of Sexual Dysfunction in Patients with DM and Comorbid Depression: Antidepressant Subgroup Analysis
| Variables | Crude | Adjusteda | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| SSRI (per 28 cDDD) | 0.96 | 0.93 | 0.98 | <0.0001 | 0.95 | 0.93 | 0.97 | <0.0001 |
| SNRI (per 28 cDDD) | 0.99 | 0.95 | 1.03 | 0.5653 | 0.96 | 0.94 | 1.01 | 0.2080 |
| NDRI (per 28 cDDD) | 1.01 | 0.92 | 1.11 | 0.8409 | 0.99 | 0.90 | 1.09 | 0.7686 |
| Mirtazapine (per 28 cDDD) | 0.99 | 0.95 | 1.02 | 0.4385 | 0.98 | 0.94 | 1.02 | 0.2728 |
| TCA/tetracyclic ATD (per 28 cDDD) | 0.92 | 0.83 | 1.02 | 0.0961 | 0.93 | 0.84 | 1.03 | 0.1533 |
| SARI (trazodone) (per 28 cDDD) | 0.94 | 0.86 | 1.04 | 0.2193 | 0.93 | 0.85 | 1.03 | 0.1508 |
| RIMA (per 28 cDDD) | 0.96 | 0.86 | 1.07 | 0.4232 | 0.97 | 0.86 | 1.08 | 0.5189 |
Notes: aAdjustment for seven types of ATDs, age, region of residence, income, comorbidities, adapted Diabetes Complications Severity Index score.
Abbreviations: SSRI, selective serotonin reuptake inhibitors; SNRI, serotonin/norepinephrine reuptake inhibitors; NDRI, norepinephrine-dopamine reuptake inhibitors; ATD, antidepressant; SARI, serotonin antagonist and reuptake inhibitor; RIMA, reversible inhibitor of monoamine oxidase A.