Table 6.
Time-Dependent Cox Regression Analysis of SSRI Effect on Patients with DM and Comorbid Depression: Sexual Dysfunction Subgroup Analysis
| Variables | Crude | Adjusteda | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| Outcome: Libido | ||||||||
| SSRI (per 28 cDDD) | 0.92 | 0.77 | 1.10 | 0.3789 | NAb | |||
| Outcome: Erection | ||||||||
| SSRI (per 28 cDDD) | 0.94 | 0.92 | 0.97 | <0.0001 | 0.95 | 0.92 | 0.97 | <0.0001 |
| Outcome: Ejaculation | ||||||||
| SSRI (per 28 cDDD) | 0.93 | 0.82 | 1.07 | 0.3259 | NAb | |||
Notes: aAdjusted for all covariates (age, urbanization, income, aDCSI, comorbidities, SSRI, SNRI, NDRI, Mirtazapine, TCA, SARI, MAOI). bAdjusted hazard ratio cannot be analyzed due to the small sample size. Dysfunction of libido: ICD-9-CM codes 302.71; dysfunction of the erection:ICD-9-CM codes 302.72 and 607.84, dysfunction of ejaculation: ICD-9-CM codes 302.74 and 302.75, and dysfunction of other causes: ICD-9-CM codes 302.70, 302.76, 302.79, and V41.7.
Abbreviations: aDCSI, adapted Diabetes Complications Severity Index; SSRI, selective serotonin reuptake inhibitors; SNRI, serotonin/norepinephrine reuptake inhibitors; NDRI, norepinephrine-dopamine reuptake inhibitors; TCA, tetracyclic antidepressant; SARI, serotonin antagonist and reuptake inhibitor; RIMA, reversible inhibitor of monoamine oxidase A.