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. 2020 May 5;6:13. doi: 10.1038/s41526-020-0103-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, c Changes in markers of resorption (a) and formation (c) (% of pre-flight) were extracted from the studies that reported both in-flight and post-flight measurements and fit to a piece-wise function: a sigmoidal in-flight, exponential post-flight; c linear in-flight and post-flight. Black line/red band: mean fit/95% CI, studies are arranged in order of mission duration (gray background). b The effect of spaceflight duration on post-flight decay constant (τ_decay) of resorption markers was modeled using exponential function for all flight durations (top) or linear function for mission durations <90 days (bottom). Black line/red band: mean fit/95% CI. d Forest plot of rates of post-flight changes in formation markers sorted by mission duration. Red circles: studies with in- and post-flight data, black circles—studies with only post-flight data. Gray diamond/band: overall estimate ± 95% CI.