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. 2020 May 5;10:7593. doi: 10.1038/s41598-020-64585-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Light microscopic analysis of the sciatic nerves from STZ-diabetic mice. (a) Gross anatomical findings of Toluidine blue stained semithin sciatic nerve sections from control and STZ animals using light microscopy (LM). Inset shows a representative region in x2-magnification. (b–d) Quantitative findings of the control (Ctrl) and the STZ groups (n = 3 each) comparing the three parameters b) ‘axon density’, (c) ‘myelin density’ (i.e. the myelin fraction within the nerve cross-sectional area (CSA)) and (d) ‘average myelination’ (i.e. myelin area per axon); n.s. = nonsignificant, unpaired two-sided t-test. (e) Histogram plot showing the frequency distribution of the equivalent axon radius within the population of all myelinated axons inside the nerve CSA. Each bar indicates group mean ± s.d. (n = 3 each). *p < 0.05, **p < 0.01, ***p < 0.001, unpaired two-sided t-test.