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. 2020 May 5;10:7593. doi: 10.1038/s41598-020-64585-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ultrastructural analysis of the sciatic nerves from STZ-diabetic mice. (a) Representative ultrastructural findings from control and STZ animals using electron microscopy (EM). Red asterisks indicate myelin infoldings. (b–d) Quantitative findings of the control (Ctrl) and the STZ groups comparing the three parameters (b) Unmyelinated ‘axon density’ (per image frame, n = 16 vs. 17 frames), (c) ‘Unmyelinated fibre area’ (i.e. the unmyelinated fibre fraction per image frame, n = 16 vs. 17 frames) and d) ‘Unmyelinated axon size’ (i.e. all unmyelinated fibres within the image frames considered, median and quartiles indicated, n = 1646 (Ctrl) vs. 878 (STZ)); *=p < 0.05, n.s. = nonsignificant, unpaired two-sided t-test.