Table 1.
Subjects’ characteristics.
| MAA (n = 56) Maastricht | AMS (n = 42) Amsterdam | |
|---|---|---|
| Age | 59.1 ± 1.0 | 54.9 ± 1.1 |
| Weight (kg) | 96.5 ± 1.3 | 116.3 ± 2.0 |
| BMI (kg/m2) | 31.2 ± 0.4 | 34.8 ± 0.5 |
| Waist/hip ratio | 0.95 ± 0.01 | 1.05 ± 0.01 |
| Fasting insulin (mU/ml) | 16.80 ± 0.79 | 20.02 ± 1.24 |
| Fasting glucose (mmol/l) | 6.06 ± 0.07 | 5.76 ± 0.09 |
| HOMA-IR | 4.5 ± 0.2 | 5.1 ± 0.3 |
| HOMA-B% | 136.3 ± 7.5 | 192.0 ± 15.3 |
| HbA1c (%) | 5.58 ± 0.05 | 5.74 ± 0.05 |
| Fasting TAG | 1.30 ± 0.10 | 1.50 ± 0.11 |
| Rd (umol*kg-1*min-1)* | 23.34 (10.7–51.4) | 26.1 (10.1–40.0) |
| Suppression EGP (%)* | 44.1(17.4–79.1) | 55.6 (30.8–85.0) |
| Suppression FFA (%)* | 45.3(−6,1–84.1) | 74.4(53.9–92.1) |
HOMA-IR: homeostasis model assessment for insulin resistance, HOMA-B%: homeostasis model assessment for beta-cell function, HbA1c: glycated haemoglobin, TAG: triacylglycerol, Rd: rate of disappearance, EGP: endogenous glucose production by the liver, FFA: free fatty acids. Data are expressed as mean ± SEM. Clamp-results are expressed as mean (range). *due to differences in clamp procedures (see Methods) between centers, no statistical comparison was made between cohorts.