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. 2020 May 5;10:7597. doi: 10.1038/s41598-020-64303-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of proposed mechanism of long-range (up to ~20 Å) regulation between the tip of the charged terminus (CT) and the central hydrophobic domain (CHD) of aggregation-prone partially folded helical states. This coupling is lost at distances >20 Å and is absent for the non-aggregating helically folded and the unfolded states.