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. 2020 May 5;5:59. doi: 10.1038/s41392-020-0155-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — MCU-induced mitochondrial Ca²⁺ uptake promotes CRC growth in vivo. a Dissected tumors from sacrificed mice and tumor growth curves of subcutaneous xenograft tumor developed from LS174T cells, treated as indicated. b Representative immunohistochemistry staining images of Ki67 in xenograft tumors developed from LS174T cells, treated as indicated. *P < 0.05; **P < 0.01. MCU mitochondrial calcium uniporter, CRC colorectal cancer, Ca²⁺ calcium