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. 2020 May 5;3:210. doi: 10.1038/s42003-020-0893-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative double-immunostaining with A6/Hnf4α, Sox9/Hnf4α, A6/Sox9, CK19/Hnf4α or Sox9/Ki67 in 6M, 12M HKO livers with tumors or 12M control livers (scale bars, 50 μm) (n = 3). b Srsf2 protein levels were detected by western blotting analysis at indicated ages of control and mutant livers. c Volcano plot showed up-regulated (red) and down-regulated (green) genes of tumors versus non-tumors of 12M mutant mice. Significance cutoff value was set at P = 0.05 in −log10 scale (horizontal dashed line) and fold change cutoffs at −1 and 1 in log2 scale (vertical dashed lines). d Volcano plot showed dots corresponding to up-regulated genes including progenitor markers (light-blue), oncofetal gene markers (brown) and HCC progression markers (pink), and down-regulated genes containing mature hepatocyte markers (green) and HCC suppressor markers (purple). e, f Comparison of differentially expressed genes among 12M tumors, 2M HKO livers and adult liver progenitor cells (LPCs).