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. 2020 May 5;3:210. doi: 10.1038/s42003-020-0893-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Comparison of Igf2 and H19 mRNA levels in 12M Srsf2^f/f, non-tumors or tumors of 12M mutant mice (n = 3). Note that qPCR cycles calculated as ΔCt values relative to the mean of β-actin. c Bubble diagram of potential pathways and biological processes based on Gene Ontology and KEGG analysis using the differentially expressed genes of 12M tumor versus non-tumors. d Igf2 and relevant pathways were activated in tumors of 12M mutant mice, addressed by western blotting analysis. Note that N for non-tumor and T for tumor; e Genomic CpG methylation ratios of H19 ICR1 and Igf2 P2 in 12M non-tumors and tumors (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. matched control by Student’s t test (b, d).