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. 2020 May 5;10:7598. doi: 10.1038/s41598-020-64564-6

Table 1.

Patient characteristics.

Total Non-recurrent Recurrence p value
(n = 267) (n = 235) (n = 32)
Patient age
mean ± SD. 50.7 ± 10.8 50.9 ± 10.7 49.6 ± 11.6 0.468
Median(IQR) 51.0 (43.0–58.0) 51.0 (43.0–58.0) 48.5 (41.5–56.5)
Menopausal status
premenopause 133 (50.0) 114 (48.7) 19 (59.4) 0.258
postmenopause 133 (50.0) 120 (51.3) 13 (40.6)
Imaging
Rim enhancement
No 178 (66.7) 162 (68.9) 16 (50.0) 0.033
Yes 89 (33.3) 73 (31.1) 16 (50.0)
Peritumoral edema
No 163 (61.1) 145 (61.7) 18 (56.3) 0.553
Yes 104 (39.0) 90 (38.3) 14 (43.8)
BPE grade
minimal 143 (53.8) 125 (53.4) 18 (56.3) 0.144
mild 53 (19.9) 51 (21.8) 2 (6.3)
moderate 43 (16.2) 35 (15.0) 8 (25.0)
marked 27 (10.2) 23 (9.8) 4 (12.5)
Ipsilateral vascularity
Mean ± SD 2.0 ± 1.8 1.9 ± 1.7 3.0 ± 2.4 0.010
Median (IQR) 2.0 (1.0–3.0) 2.0 (0.0–3.0) 3.0 (1.0–5.0)
Immunohistochemical staining
Subtype
luminal A 63 (23.8) 58 (24.9) 5 (15.6) 0.314
luminal B 124 (46.8) 106 (45.5) 18 (56.3)
HER2 +  34 (12.8) 32 (13.7) 2 (6.3)
Triple negative cancer (TNC) 44 (16.6) 37 (15.9) 7 (21.9)
Staging
0 13 (4.9) 13 (5.6) 0 (0.0) 0.001
I 77 (29.1) 70 (29.9) 7 (22.6)
II 126 (47.6) 116 (49.6) 10 (32.3)
III 45 (17.0) 33 (14.1) 12 (38.7)
IV 4 (1.5) 2 (0.9) 2 (6.5)
Texture analysis
Kurtosis
Mean ± SD 2.9 ± 0.7 2.9 ± 0.7 2.9 ± 0.8 0.802
Median(IQR) 2.8 (2.5–3.2) 2.8 (2.5–3.2) 2.7 (2.5–3.2)
Skewness
Mean ± SD −0.1 ± 0.4 −0.1 ± 0.4 0.0 ± 0.4 0.031
Median (IQR) −0.1 (−0.3–0.1) −0.2 (−0.4–0.1) −0.1 (−0.2–0.3)
Entropy
Mean ± SD 2.0 ± 0.6 2.0 ± 0.6 2.1 ± 0.5 0.359
Median (IQR) 1.9 (1.6–2.4) 1.9 (1.6–2.4) 2.0 (1.8–2.5)
Perfusion parameters
Ktrans
25percentile
Mean ± SD 0.2 ± 0.1 0.2 ± 0.1 0.2 ± 0.1 0.325
Median (IQR) 0.1 (0.1–0.2) 0.1 (0.1–0.2) 0.2 (0.1–0.2)
50percentile
Mean ± SD 0.3 ± 0.2 0.3 ± 0.2 0.3 ± 0.1 0.929
Median (IQR) 0.2 (0.2–0.3) 0.2 (0.2–0.3) 0.2 (0.2–0.4)
75percentile
Mean ± SD 0.4 ± 0.3 0.4 ± 0.3 0.4 ± 0.1 0.858
Median (IQR) 0.3 (0.2–0.5) 0.3 (0.2–0.5) 0.3 (0.2–0.5)
Mean
Mean ± SD 0.9 ± 9.7 1.0 ± 10.3 0.3 ± 0.1 0.962
Median (IQR) 0.2 (0.2–0.3) 0.2 (0.2–0.3) 0.2 (0.2–0.4)
Kep
25percentile
Mean ± SD 0.3 ± 0.4 0.3 ± 0.4 0.3 ± 0.2 0.211
Median (IQR) 0.3 (0.2–0.4) 0.3 (0.2–0.4) 0.3 (0.2–0.4)
50percentile
Mean ± SD 0.6 ± 0.8 0.6 ± 0.9 0.5 ± 0.2 0.783
Median (IQR) 0.5 (0.4–0.6) 0.5 (0.4–0.6) 0.5 (0.4–0.6)
75percentile
Mean ± SD 0.9 ± 1.7 0.9 ± 1.8 0.8 ± 0.3 0.921
Median (IQR) 0.7 (0.5–0.9) 0.7 (0.5–0.9) 0.7 (0.6–0.9)
mean
Mean ± SD 0.7 ± 1.7 0.7 ± 1.8 0.6 ± 0.2 0.742
Median (IQR) 0.5 (0.4–0.7) 0.5 (0.4–0.7) 0.5 (0.5–0.6)
Ve
25percentile
Mean ± SD 102.1 ± 1636.1 115.4 ± 1740.0 0.4 ± 0.1 0.197
Median (IQR) 0.4 (0.3–0.5) 0.4 (0.3–0.5) 0.4 (0.3–0.5)
50percentile
Mean ± SD 133.6 ± 2141.5 151.0 ± 2277.5 0.5 ± 0.2 0.681
Median (IQR) 0.5 (0.4–0.6) 0.5 (0.4–0.6) 0.5 (0.4–0.6)
75percentile
Mean ± SD 133.7 ± 2141.5 151.1 ± 2277.5 0.6 ± 0.2 0.960
Median (IQR) 0.6 (0.5–0.8) 0.6 (0.5–0.8) 0.6 (0.5–0.7)
mean
Mean ± SD 110.1 ± 1763.4 124.4 ± 1875.3 0.5 ± 0.2 0.611
Median (IQR) 0.5 (0.4–0.6) 0.5 (0.4–0.6) 0.5 (0.4–0.6)