Table 5.
DAVID functional annotations for differently expressed proteins identified in seminal plasma.
| Men with primary infertility compared with the control group | |
| Key Processes (# of proteins) | |
| Overexpressed Proteins | Cell migration (5), Oxidation-reduction process (5), Cell adhesion (4), Response to drug (5), Carbohydrate metabolic process (4), ECM organization (4), Angiogenesis (3) |
| Underexpressed Proteins | Coagulation (2), Positive regulation of serine-type endopeptidase activity (2), Negative regulation of sperm motility (2), Protein heterooligomerization (2) |
| Proteins Unique to Primary Infertility | Oxidation-reduction process (1), Immune response (1), Regulation of protein stability (1), Cell-cell adhesion (2) |
| Key Functions (# of proteins) | |
| Overexpressed Proteins | Calcium ion binding (6), Identical protein binding (6), Structural molecule activity (5), Myosin V binding (3), GDP binding (3), Structural constituent of cytoskeleton (3) |
| Underexpressed Proteins | Protease binding (2) |
| Proteins Unique to Primary Infertility | GTPase activity (1), Protein binding (3), Iron-ion binding (1), GTPase inhibitor activity (1) |
| Men with secondary infertility compared with the control group | |
| Key Processes (# of proteins) | |
| Overexpressed Proteins | Platelet degranulation (6), Negative regulation of endopeptidase activity (5), Carbohydrate metabolic process (5), Proteolysis (6), Cell-cell adhesion (4), PKA signaling (2) |
| Underexpressed Proteins | Coagulation (2), Negative regulation of sperm motility (2), Positive regulation of serine-type endopeptidase activity (2), antibacterial humoral response (20, protein heterooligomerization (2) |
| Proteins Unique to Secondary Infertility | ECM organization (3), Protein refolding (2), Cellular iron ion homeostasis (2), Actin cytoskeleton reorganization (2), Negative regulation of endopeptidase activity (2) |
| Key Functions (# of proteins) | |
| Overexpressed Proteins | Cadherin binding involved in cell-cell adhesion (6), Endopeptidase inhibitor activity (3), GTPase activity (4), Unfolded protein binding (3), GTP binding (4), Structural molecule activity (3), Calcium-dependent protein binding (3) |
| Proteins Unique to Secondary Infertility | Ferroxidase activity (2), Serine-type endopeptidase inhibitor activity (2), Unfolded protein binding (2), Identical protein binding (3) |