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. 2020 May 5;11(5):320. doi: 10.1038/s41419-020-2535-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a GSEA validating the correlation between SVEP1 expression and the downregulated expression of genes in HCC tissues. b, c. GSE45436 and TCGA validation of the expression of SVEP1 in HCC and para-tumor tissues. d, e Kaplan–Meier survival curve of TCGA data to validate the correlation between the expression of SVEP1 and HCC patient OS and DFSs. f, g. Correlation analysis between the SVEP1 IHC score and clinicopathological parameters (tumor size and satellite nodules). h, i. Kaplan–Meier survival curve showing the correlation between the SVEP1 IHC score and the OS of a subgroup of HCC patients tumor size ≥3 cm and satellite nodule positive patients. j, k Kaplan–Meier survival curve showing the correlation between the SVEP1 IHC score and DFS of a subgroup of HCC patients (tumor size ≥3 cm and satellite nodules positive patients).