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. 2020 May 5;10:7557. doi: 10.1038/s41598-020-64536-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional comparison of a “bipod” BsAb produced using either large-scale (A) or high-throughput (B) methods. (A) Graph of the % CARNAVAL cell lysis vs concentration of antibody overlaid with the relative T cell activation, based on CD25 expression. The BsAb displays an EC₅₀ for CARNAVAL cell killing of 32 pM. (B) The same experiment in (A) was performed using the BsAb generated in small scale using high-throughput methods, and it shows the antibody has similar activity, displaying an EC₅₀ for CARNAVAL cell killing of 23 pM.