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. 2020 May 5;10:7557. doi: 10.1038/s41598-020-64536-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High-throughput generation of highly pure BsAbs allows interrogation of larger panels of BsAbs and analysis of wider functional questions. (A) Examples of CARNAVAL cell killing and T cell activation analysis using the same experiments as in (Fig. 4). BsAbs displayed a range of activities, from almost total cell killing, to total lack of activity. (B) The activities of a panel of BsAbs was analyzed and correlated with antigen binding epitope. Generation of large panels of highly pure, functional BsAbs allows interrogation of a range of antigen-binding affinities, epitopes, and format which generally present a technical challenge of purifying BsAbs since small levels of impurity can lead to large changes in activity.