Table 3.
Effect of the pitavastatin-fluconazole (FLC) combination against different Candida strains.
| Candida Strains | MIC (µg/ml) | ΣFICIa | Interaction | |||
|---|---|---|---|---|---|---|
| FLC | Pitavastatin | |||||
| Alone | Combined | Alone | Combined | |||
| C. albicans SC5314 | 0.125 | 0.0312 | 4 | 1 | 0.50 | SYN |
| C. albicans NR-29448 | 256 | 4 | 8 | 0.25 | 0.05 | SYN |
| C. albicans NR-29437 | 128 | 4 | 8 | 0.5 | 0.09 | SYN |
| C. albicans ATCC 26790 | 128 | 4 | 8 | 0.5 | 0.09 | SYN |
| C. albicans ATCC MYA-573 | 128 | 4 | 16 | 4 | 0.28 | SYN |
| C. albicans TWO7241 | 32 | 16 | 8 | 4 | 1.00 | IND |
| C. albicans TWO7243 | 64 | 16 | 64 | 4 | 0.31 | SYN |
| C. albicans SC-TAC1G980E | 2 | 0.25 | 32 | 4 | 0.25 | SYN |
| C. albicans SC-MRR1P683S | 2 | 1 | 8 | 2 | 0.75 | ADD |
| C. glabrata ATCC 66032 | 4 | 1 | 64 | 16 | 0.50 | SYN |
|
C. glabrata ATCC MYA-2950 |
8 | 1 | 64 | 16 | 0.38 | SYN |
| C. glabrata ATCC 2001 | 4 | 0.5 | 64 | 16 | 0.38 | SYN |
| C. glabrata HM-1123 | 4 | 1 | 64 | 16 | 0.50 | SYN |
| C. auris 385 | 256 | 32 | 128 | 32 | 0.38 | SYN |
| C. auris 386 | 256 | 64 | 128 | 16 | 0.38 | SYN |
| C. auris 388 | 256 | 64 | 64 | 16 | 0.50 | SYN |
| C. auris 389 | 256 | 32 | 64 | 8 | 0.25 | SYN |
| C. auris 390 | 256 | 16 | 64 | 16 | 0.31 | SYN |
aΣFICI (fractional inhibitory concentration index) is used to measure the interaction between the tested combinations. ΣFICI interpretation corresponded to the following definitions: synergism (SYN), ΣFICI ≤ 0.5; additivity (ADD), ΣFICI > 0.5 and ≤1; and indifference (IND), ΣFICI > 1 and ≤4.