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. 2020 May 5;10:7507. doi: 10.1038/s41598-020-64558-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The relationship between serum Tetranectin levels with circulating markers of fibrosis – PICP (a), PINP (b), CITP (c), and PINP + PICP/CITP ratio (d), were assessed using correlations and Pearson or Spearman correlation coefficients; and by stratifying the patient population based on the median serum Tetranectin levels, PICP (e), PINP (f), CITP (g), and PINP + PICP/CITP ratio (h), and MMP2 (i). Circulating fibrosis markers were quantified using ELISA and radioimmunoassy. Cohort size, n = 32. Data represent mean ± SD and analysis performed using independent t-test or Mann-Whitney test.