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. 2020 Apr 22;43:100789. doi: 10.1016/j.dcn.2020.100789

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 4 — Effect of 2-week withdrawal from cocaine exposure during adolescence on BDNF-mediated signaling pathways in the PrhC.

Rats were treated with cocaine or saline from PND 28 to PND 42. Two weeks after the end of treatment (PND 56), rats were tested for NOR and sacrificed immediately after the test. Panel a shows the activation of Akt (expressed as a ratio: pAkt S473/Akt 60 kDa, panel a) and of ERK2 (expressed as a ratio: pERK2 T185/Y187/ERK2 42 kDa, panel b) protein levels are shown in the whole homogenate of the PrhC. Below each graph, representative immunoblots are shown for pAkt S473, Akt, pERK2 T185/Y187 and ERK2 proteins in the homogenate of PrhC.

Results are expressed as percentages of saline-treated rats not exposed to NOR (saline-no test). Histograms represent the mean ± SEM of six to seven rats per group. ^###p < 0.001 vs. cocaine-no test (two-way ANOVA followed by Tukey HSD test).