Fig. 7.

Effect of 2-week withdrawal from cocaine exposure during adolescence on PSD95 protein levels in the PrhC.

Rats were treated with cocaine or saline from PND 28 to PND 42. Two weeks after the end of treatment (PND 56), rats were tested for NOR and sacrificed immediately after the test. PSD95 protein levels were shown in the post-synaptic density fraction of the PRh. Below the graph, representative immunoblots are shown for PSD95 and β-Actin proteins in the PSD fraction of PrhC.

Results are expressed as percentages of saline-treated rats not exposed to NOR (saline-no test). Histograms represent the mean ± SEM of six to seven rats per group. *p < 0.05 vs. saline-no test rats; ^#p < 0.05 vs. cocaine- no test (two-way ANOVA followed by Tukey HSD test).