Table 3.
Functional categories and predicted roles for differentially expressed genes that impact tissue metabolism, accretion, and function (P < 0.01) in fetal cerebrum presented as upregulation/downregulation in fetuses from restricted (RES) heifers compared with control (CON)
| Category | Functional annotationa | Total genesb | Upreg.c | Downreg.d | P-valuee |
|---|---|---|---|---|---|
| Hippocampus and neurogenesis | Hippo signaling pathway | 5 | 5 | 0 | <0.001 |
| Collagen | 9 | 9 | 0 | ||
| Netrin | 5 | 5 | 0 | ||
| SMAD | 4 | 4 | 0 | ||
| Developmental protein | 9 | 8 | 1 | ||
| Metal-binding | Iron-binding | 4 | 4 | 0 | 0.006 |
| Zinc-binding | 10 | 10 | 0 | ||
| Copper-binding | 2 | 2 | 0 | ||
| Nickel-binding | 1 | 1 | 0 | ||
| Calcium-binding | 6 | 5 | 1 | ||
| Cytoskeleton | Actin remodeling | 5 | 5 | 0 | 0.003 |
aProposed function of differentially expressed genes that fall under a specific category.
bTotal number of differentially expressed genes associated within a specific function.
cNumber of differentially expressed genes that are upregulated in fetuses from RES vs. CON heifers.
dNumber of differentially expressed genes that are downregulated in fetuses from RES vs. CON heifers.
eProbability value associated with a specific category. P-value as presented is for the entire pathway, not individual genes within a pathway.