Figure 8.

Melanoma Cell Lines and Primary Single Melanoma Cells Are Distributed Along Path between Extremes in Differentiation States

Projections along the terminally differentiated ($S{M}_T$) versus de-differentiated ($S{M}_D$) state axes for each melanoma cell line included in the CCLE (A) and primary melanoma cells (B). Values for the terminally differentiated and de-differentiated state metrics were estimated by RNA-seq data for cell lines associated with the CCLE and by scRNA-seq data for primary melanoma cells. Symbols for primary melanoma cells were colored differently for each patient sample. The dotted line corresponds to a reciprocal relationship between the $S{M}_T$ and $S{M}_D$ state metrics (i.e., $S{M}_T$ = 1 - $S{M}_D$).