Figure 4.
Mitochondrial Bioenergetics Failure Occurs in Skeletal Muscle Satellite Cells Isolated from Early Presymptomatic SOD1G93A Mice
(A) Representative trace of oxygen consumption rate (OCR) in skeletal muscle satellite cells isolated from early presymptomatic SOD1G93A mice (55 days) and their wild-type control littermates (WT).
(B) Individual parameters obtained for basal respiration, ATP production, maximal respiration, and spare respiratory capacity. Each data point represents an OCR measurement. Data are presented as mean ± SEM, ∗∗p < 0.001, ∗∗∗p < 0.0001 relative to WT control, p values obtained from unpaired Student's t test. Data from four independent experiments, with each sample tested in quadruplicate.