Table 1.
Histopathological study of liver samples 21 days after AAV-HBV- or AAV-HBV/HDV injection and untreated wild-type animals.
| Pathological finding | WT C57BL/6 |
||
|---|---|---|---|
| Control |
AAV-HBV |
AAV-HBV/HDV |
|
| (n = 6) | (n = 6) | (n = 6) | |
| Inflammatory foci | (3/1) | (3/1) | (6/2-3) |
| Single cell necrosis | (-) | (-) | (6/1-2) |
| Difuse Hepatocyte hypertrophy | (-) | (-) | (6/2) |
| Increased mitosis | (-) | (-) | (6/2-3) |
The indicated values correspond to: (Number of mice affected/degree of severity). The degree of severity was scored from 0 to 5. (-)=0.
AAV, adeno-associated virus.