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. 2020 Apr 29;7:137. doi: 10.3389/fvets.2020.00137

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Copyright © 2020 Kroeker, Smid, Embury-Hyatt, Collignon, Pinette, Babiuk and Pickering.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liver histopathology and in situ hybridization. Livers from animals in the ID-IN-SQ combined inoculation group had small numbers of lesions (A, arrow) which on higher magnification (B) were characterized by areas of hepatocyte necrosis (arrows) and loss with replacement by a mixed inflammatory infiltrate (*). Most livers from intranasally inoculated animals had numerous lesions (D, arrows) which on higher magnification (E) were characterized by replacement of normal hepatocytes (*) with large areas of necrosis (delineated by arrows). Numerous lesions were also observed in several livers from the intradermally inoculated group (G, arrows). In this group there was significant hemorrhage associated with the areas of hepatocyte loss (H). The presence of RVFV in the lesions was confirmed using in situ hybridization, in bright pink (C,F,I).