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. 2020 Apr 29;11:725. doi: 10.3389/fmicb.2020.00725

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Copyright © 2020 Zitzmann, Schmid, Ruggieri, Perelson, Binder, Bartenschlager and Kaderali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Percentage increase and decrease of model parameters of the antiviral ( $\hat{k_{1}}, \hat{k_{r e}}, \hat{μ_{R_{V}}}$ ) and countermeasure ( $\hat{k_{r i g}}, \hat{k_{j a k}}$ ) effect of the HIR and DV on model parameters as a function of time (Equations 25 to 28; Table 1). The antiviral HIR mediated inhibition of the (A) translation initiation complex formation k₁, (B) naïve cell infection/reinfection k_re, (C) cytosolic DV RNA degradation. The DV mediated countermeasure of (D) RIG-I pathway k_rig and (E) JAK/STAT pathway k_jak, as well as (F) the ISG protein concentration over time. Note that $\hat{k_{1}}$ and $\hat{μ_{R_{V}}}$ are ISG dependent, while $\hat{k_{r e}}$ is IFN dependent.