Figure 1.

Course of P. chabaudi challenge infection in BALB/c mice undergoing different stages of primary B. microti infection. Test BALB/c mice were initially infected with B. microti and then challenge-infected with P. chabaudi at different time points (on days 0, 7, 14, 28, or 56) post primary infection. Control mice received P. chabaudi alone. Courses of parasitemia (A–C) and survival rates (D–F) of control and test mice are presented. Results are expressed as mean percent parasitemia values ± the standard deviation (SD) of five or six mice. Mean percent parasitemia values are calculated from individual percent parasitemia levels taken from all surviving mice at each specific time point. Experiment shown is representative of three independent experiments. Experiments of challenge infection on days 0, 7, and 14 (A,D) belonged to a single cohort and as such share the same control group.