Figure 4.

Course of P. chabaudi challenge infection in SCID and BALB/c mice chronically infected with B. microti. Test SCID and BALB/c mice were initially infected with B. microti and then challenged with P. chabaudi on day 28 after primary infection. Control SCID and BALB/c mice received P. chabaudi alone. Parasitemia (A), hematocrit (B), body weight (C), and survival rates (D) were monitored over a period of 28 days after challenge infection with P. chabaudi. Results are expressed as mean values ± the SD of six mice. Mean percent parasitemia, hematocrit, and body weight values are calculated from individual values taken from all surviving mice at each specific time point. Asterisks indicate statistically significant differences (*P < 0.05 and **P < 0.005 between different groups. Ns = P > 0.05).