Figure 3.

Tumor mutation burden and survival outcome in EGFR-mutant patients. (A) Progression-free survival of EGFR-mutant patients using first generation of EGFR-TKIs stratified by tertiles of TMB. (B) ORR of EGFR-TKIs in EGFR-mutant patients of TMB L/I/H groups. (C) Progression-free survival of EGFR-mutant patients divided by three mutational subtypes. (D) Progression-free survival of EGFR-mutant patients divided by DDR genes status. (E) Hazard ratio (Mantel–Haenszel method) and p-value (log-rank) for subgroups evaluating PFS of EGFR-TKIs in EGFR-mutant patients stratified by low vs. intermediate/high TMB.