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. 2020 Apr 29;10:480. doi: 10.3389/fonc.2020.00480

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Copyright © 2020 Lin, Shi, Zhao, He, Fan, Xu, Shao, Yu and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor mutation burden and survival outcome in patients receiving chemotherapy. (A) Progression-free survival of EGFR/ALK WT patients using pemetrexed/platinum stratified by tertiles of TMB. (B) ORR of pemetrexed/platinum chemotherapy in EGFR/ALK WT patients of TMB L/I/H groups. (C) Progression-free survival of EGFR/ALK WT patients divided by TP53 status. (D) The proportion of TP53 mutant or WT patients in TMB L/I/H groups. (E) Hazard ratio (Mantel–Haenszel method) and p-value (log-rank) for subgroups evaluating PFS of pemetrexed/platinum in EGFR/ALK WT patients stratified by low vs. intermediate/high TMB.