Table 1.
Related LncRNAs in Diabetic Peripheral Neuropathy
| LncRNAs | Localization | Potential Regulatory Mechanism of LncRNAs | References |
|---|---|---|---|
| BC168687↑ | DRG neurons of diabetic rats | TWL↓, MWT↓ TRPV1 receptors↑, TNF-α and IL-1β↑ P2X7↑, NO↑ |
[24,25] |
| uc.48+↑ | SCG of diabetic sympathetic neuropathy; DRG neurons of diabetic rats; serum samples of diabetic patients | P2X7↑ TWL↓, MWT↓ P2X3 protein and mRNA↑ |
[26,32] |
| NONRATT021972↑ | DRG neurons of diabetic rats | TNF-α↑ P2X3 receptor↓ P2X7 mRNA and protein↑ |
[33–36] |
| KCNA2-AS↑ | First-order sensory neurons of rat DRG | Kcna2↓ Total voltage-gated potassium current↓ Excitability in DRG neurons↑ |
[39] |
| XIST↑ | Spinal cord of CCI rats | Regulating of miRNA-137/TNFAIP1 axis | [41] |
| CCAT1↓ | Spinal dorsal horn, DRG neurons, hippocampus, and ACC of CCI rats | Pain threshold↑ SGK3↑by modulating miR-155 axis |
[38] |
| MRAK009713↑ | DRG neurons of CCI rats | P2X3 receptor↓ | [40] |
| MALAT1↑ | Rats of diabetic gastroparesis, diabetic patients with diabetic gastroparesis symptoms | α-SMA↓ Influencing the potential of cell migration Cell apoptosis in human gastric smooth muscle cells↑ | [42] |
Note: The arrows indicate up/down expression levels.
Abbreviations: α-SMA, α-smooth muscle aorta; DRG, dorsal root ganglion; SCG, superior cervical ganglia; SGK3, serum and glucocorticoid regulated protein kinase 3; TNFAIP1, tumor necrosis factor, alpha-induced protein 1; TRPV1, transient receptor potential vanilloid type 1.