TABLE 1.

PICOS framework for determination of eligibility of review question.

Criteria	Determinants
Problem	Anecdotal data suggests that MET, a drug used to treat type II diabetes mellitus, affects the ability of macrophages to control intracellular Mtb.
Intervention	Does MET affect the ability of macrophages to control intracellular Mtb.
Comparison	Absence of MET.
Outcomes	Effect on macrophage phagolysosomal activity.
	Synergistic effect with current TB therapy.
Study setting	Includes studies worldwide.

MET, metformin; Mtb, Mycobacterium tuberculosis; PICOS, Population/Problem, Intervention, Comparison, Outcomes and Study setting; TB, tuberculosis.