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. 2020 Apr 29;11:454. doi: 10.3389/fphar.2020.00454

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Copyright © 2020 Man, Chen, Wu, Reifenberg, Daiber, Münzel, Xia and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal pentaerythritol tetranitrate (PETN) treatment leads to blood pressure and kidney injury reduction in early ages of female offspring (16 weeks). Parental spontaneously hypertensive rats (SHR) were treated with or without PETN (50 mg/kg/day) during pregnancy and lactation periods. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) (A); heart rate (B) and body weight (C) were measured in the offspring at 16 weeks. Column represents mean ± SEM, n=25−26. Plasma samples were obtained from the female offspring (16 weeks) from each group for the measurement of the blood urea nitrogen (BUN) (D) and potassium ion concentration (E) using a blood chemical analyser (Reflotron, Roche Co., Germany). Student’s t test was used for comparison of PETN group with control group. *P < 0.05; **P < 0.01; vs. control group.