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. 2020 Apr 29;11:454. doi: 10.3389/fphar.2020.00454

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Copyright © 2020 Man, Chen, Wu, Reifenberg, Daiber, Münzel, Xia and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal pentaerythritol tetranitrate (PETN) treatment downregulates profibrotic signaling pathways in the female offspring. Parental spontaneously hypertensive rats (SHR) were treated with or without PETN (50 mg/kg/day) during pregnancy and lactation periods. The mRNA expression of tumor necrosis factor (TNF-α) (A), Wnt4 (B), transforming growth factor beta (TGF-β) (C) and matrix metalloproteinase (MMP2 and MMP9) (D, E) in the kidney of 16-week-old offspring were studied with quantitative real-time PCR. RNA polymerase II was used as reference gene for qPCR. Column represents mean ± SEM, n=10–11. Student’s t test was used for comparison of PETN group with control group. *P < 0.05, **P < 0.01; vs. control group.