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. 2020 Apr 29;11:454. doi: 10.3389/fphar.2020.00454

Figure 7.

Figure 7

Maternal pentaerythritol tetranitrate (PETN) treatment leads to reduction in macrophage infiltration in kidney of female offspring. Parental spontaneously hypertensive rats (SHR) were treated with or without PETN (50 mg/kg/day) during pregnancy and lactation periods. Different cell surface markers of antigen presenting cells were measured by the gene expression of cluster of differentiation (CD) 74 (A), CD 45 (B), CD 11B (C), CD3ϵ (D), and CE19 (E) in the kidney of 16-week-old female offspring. Proinflammatory gene expression of intercellular adhesion molecule-1 (ICAM-1) (F), vascular cell adhesion protein 1 (VCAM-1) (G) and nuclear factor kappa-light-chain-enhancer of activated B cells p105 subunit (NF-κB) (H) in the kidney of 16-week-old female offspring were measured. RNA polymerase II was used as reference gene for qPCR. Column represents mean ± SEM, n=8−12. Student’s t test was used for comparison of PETN group with control group. *P < 0.05, vs. control group.