Fig. 4.

Antigen-specific CD8+ T-cell responses after re-stimulation with BCG. Frequency of CD8+ T cells expressing at least 2 of the cytokines IL-2, TNF-α and IFN-γ in response BCG at study days 0, 14/28, 70 and 168 after vaccination (day 28 for BCG group and day 14 for all other groups). Respective response rates are indicated above each box plot. Comparisons to baseline response rates were made using McNemar's test and to baseline magnitudes with the Wilcoxon Signed rank test; no responses met the significance criteria FWER-p < 0·05. The mid-line of the box denotes the median and the ends of the box denote the 25th and 75th percentiles. Whiskers extend to the most extreme data points, no more than 1·5 times the interquartile range.