Table 3.

Voltage dependence of activation, fast inactivation, and slow inactivation.

	Activation		Fast inactivation		Slow inactivation
	V1/2 (mV)	k (mV)	V1/2 (mV)	k (mV)	V1/2 (mV)	k (mV)
WT	−18.5 ± 1.3	7.4 ± 0.4	−71.2 ± 1.3	6.8 ± 0.5	−62.2 ± 1.1	11.3 ± 0.8
Ile215Thr	−28.6 ± 1.5***	6.6 ± 0.5	−71.0 ± 1.1	4.6 ± 0.4	−69.7 ± 0.9**	7.3 ± 0.4**
Gly241Val	−30.2 ± 1.3***	7.2 ± 0.5	−75.4 ± 1.4*	5.9 ± 0.5	−72.4 ± 1.1***	8.9 ± 0.5

Values are expressed as means ± SEM. Asterisks represent significant differences between mutants and WT channels:

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.